Operant responding in opioid-deficient mice

Summary

This project studied mutant mice selectively lacking beta-endorphin, proenkephalin, prodynorphin or the combination of beta-endorphin and proenkephalin for the reinforcing effects and reward from normal diet chow, sucrose and ethanol using progressive ratio operant responding, under both substance-deprived and sated concitions.

Status: Completed
Funding: NIH/ NIDA
Category: Research