Persistent opioid use after surgery is a common morbidity outcome associated with subsequent opioid use disorder, overdose, and death. While phenotypic associations have been described in previous research publications, genetic associations have remained unidentified.
In a recent edition of Genetic Epidemiology, Aubrey C. Annis and mentors Gonçalo R. Abecasis and Chad Brummett have new insights to share on these genetic associations in their publication, “Genetic Associations of Persistent Opioid Use After Surgery Point to OPRM1 but Not Other Opioid-Related Loci as the Main Driver of Opioid Use Disorder”.