Projects and Research
Learn more about University of Michigan research and education programs, as well as the ways we are reaching communities and informing policy to prevent opioid misuse and overdose.
Browse through projects below, or click through keywords to find projects that best fit what interests you.
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Sexual Orientation, Discrimination, and Health Disparities in DSM-5 Alcohol Use Disorders
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Health, Stress, and Tobacco Use Disparities among Sexual Minority Populations
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Impacting the Opioid Crisis: Prevention, Education, and Practice for non-Prescribing Providers
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Emergency Care of the Post-Opioid Overdose Patient Project
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Michigan Safer Opioid Prescribing Toolkit
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Michigan OPEN/Michigan Emergency Department Improvement Collaborative (MEDIC) Project
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Understanding endogenous opioid drive of alcohol consumption
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Optimized Interventions to Prevent Opioid Use Disorder Among Adolescents and Young Adults in the Emergency Department
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A Prospective Study of the Nonmedical use of Prescription Medications by Adolescents
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Longitudinal Changes in Recovery from Drug Use Disorders: A National Study
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Trajectories of Nonmedical Prescription Drug Misuse
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Scenario-Tailored Opioid Messaging Program: An Interactive Intervention to Prevent Analgesic-Related Adverse Drug Events in Children and Adolescents
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A Tailored Behavioral Intervention to Increase Engagement in Pain and Opioid Use Disorder Treatment in Primary Care Settings
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Enhancing Treatment Access for Chronic Pain Patients
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Creating a Culture Shift: Promoting Medical School Education on Medication-Assisted Treatments
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Empowering dental offices to evaluate and reduce their opioid prescribing habits
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Evaluation of trends in prescribing to opioid naïve
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A Quality Improvement program to better understand our opioid prescribing and its effect on dental patients.
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First Responders Evaluation
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Opioid Harm Reduction and Treatment Quality in Acute Care
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Pilot Testing of Community Overdose Assessment Teams (COAT): A Demonstration Project
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Nonmedical Prescription Drug Misuse among Older Adults: Subtypes, Motives, and Diversion Sources
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Prescription Drug Misuse Characteristics in Adolescents and Young Adults: Influence of School Enrollment
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E-Cigarette Use and Longitudinal Changes in Cigarette Smoking and Health
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A national profile of opioid prescribing to children
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Using default opioid dosing settings to limit excessive opioid prescribing to adolescents and young adults undergoing tonsillectomy
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Feasibility of a virtual mirror visual feedback intervention for Veterans with chroniclowback pain
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Continuous low dose ketamine infusions and its effect on opioid consumption during a pain crisis in a series of patients in a pediatric hospital
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Removing Barriers to Recovery: Community Partnering for Innovative Solutions to the Opioid Crisis
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Program Evaluation for the Alternative Sentencing Bureau
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Understanding Reproductive Health Vulnerabilities in Adolescent Girls: Towards a mHealth Intervention
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Computer-Based Intervention for Battered Sheltered Women with Substance Use
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Companion Animals for Chronic Pain Management Among Community-Dwelling Adults Aged 70+: A Qualitative Exploration
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Promoting Physical Activity for Chronic Pain Management among Older Adults in Detroit: Comparing Technology-Based Strategies
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Novel Strategies to Reach Diverse Older Adults With Pain Self-Management Support
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A Low-intensity, Cognitive-Behavioral Self-Management Intervention for Chronic Musculoskeletal Pain in Older Adults
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Technology-Based Intervention For Reducing Sexually Transmitted Infections and Substance Use During Pregnancy
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Finding Useful Techniques to Upgrade Recovery Enhancement (FUTURE)
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The Effect of Marijuana Legalization on Opioid Prescriptions
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Examining the Quality of Opioid Use Disorder Treatment in a Medicaid Research Network
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Michigan Opioid Prescribing Engagement Network Pediatric Initiative
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The Opioid Epidemic: A Collaborative Workshop
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Evaluating therapeutic procedures in the clinical practice of headache medicine
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Targeting G protein βγ Subunits to Potentiate Opioid Analgesia
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Development of a Small Molecule Inhibitor of G protein-PLC interactions to increase analgesic efficacy and reduce limiting and dangerous side effects of opioid analgesics
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Selective Targeting of G protein βγ subunits with small molecules
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Addressing Opioid Prescribing Practices in Michigan
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Washtenaw Health Initiative Opioid Project
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Representation on Governor Snyder’s Opioid Commission
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The Prescription Opioid Epidemic in Michigan: Evidence, Expertise, and Recommendations for Action
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Efficacy of tramadol analgesia in murine models of inflammation and sepsis.
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Kohl’s Cares Project
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Teach Out Series: Solving the Opioid Crisis
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Neurobiology of Placebo Effects in Fibromyalgia
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MISSION-FORWARD
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MISSION- Integrated Reentry and Peer Support (I-RAPS)
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Jail Diversion Across the Continuum: An Opportunity for Planning and Reflection. Planning (JD-CORP)
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MISSION: Ending Chronic Homelessness through Permanent Housing, Integrated Treatment, Case Management, and Peer Support in Western and Central Massachusetts
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MISSION-Community Re-entry and Peer Support (RAPS)
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Evaluating Effectiveness of a Statewide Public Mental Health Re-entry Program
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MISSION-Community Re-entry for Women (CREW)
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MISSION Direct Vet- A Jail Diversion and Trauma Recovery Program
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MISSION- Western Massachusetts Integrated Reentry and Peer Support (WI-RAPS)
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MISSION-CAPE
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MISSION-CREST (Court-Related Enhanced Services for Treatment)
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MISSION-Michigan Reentry Program (Mi-REP)
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Preclinical Animal Trials to Assess the Efficacy of NMDA and Kappa-Opioid Receptor Antagonist in Treatment of Tinnitus
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2015 U-M Injury Center Opioid Overdose Summit
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Safer Opioid Prescribing Massive Open Online Course
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Prescription Opioids and Driving Risk: A Comparison by Dose and Medical Use and Misuse
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Participation as Content Expert in development of CDC Guideline for Prescribing Opioids for Chronic Pain
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Creating best practices for postoperative pain management and opioid prescribing among patients undergoing surgical and dental procedures
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Discrimination, Stress and Substance Use Disorder among Sexual Minority Adults: A Secondary Analysis of NESARC-III
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Study of State EMS Protocol for Intranasal Naloxone Administration Using a Lower Dose of Naloxone
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Opioid and Over-the Counter Analgesic Use and Knowledge among Adolescents and Young Adults: A Community Based Survey
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Clinical Decision Support Committee
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Providing Content Expertise to State Legislators
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Michigan Opioid Collaborative: A Training and Support Program for Clinicians Treating Opioid Use Disorders
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Heroin use and overdose following changes to individual-level opioid prescribing
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Primary Care Intervention to Reduce Prescription Opioid Overdoses
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Developing a Prescription Opioid Overdose Prevention Intervention
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Reducing Non-medical Opioid Use: An Automatically Adaptive mHealth Intervention
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Psychosocial Pain Management during Addictions Treatment to Improve Outcomes
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State-Level Opioid Policy Effects of Opioid Prescribing, Use and Overdose
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The Relationship between Medication-Assisted Treatment (MAT) Provider Supply and Opioid-Related Overdose Mortality
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The Opioid Epidemic: U-M Medical School M3 course
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Project STOP (Strategies Targeting Opioid and Prescription Drug Abuse)
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Development and Evaluation of Take ACTION Naloxone Training for Law Enforcement Officers: A Demonstration Project
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Law Enforcement Officers’ Perceptions of Intranasal Naloxone Training for Opioid Overdoses
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Sustaining and Strengthening Community University Partnership to Develop a Web-based Naloxone Training Curriculum for Law Enforcement Officers
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Chronic Pain Workshop
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Opioid Tapering Prior to Total Knee and Total Hip Arthroplasty
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Longitudinal Changes in Recovery from Drug Use Disorders: A National Study
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Trajectories of Nonmedical Prescription Drug Misuse
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The Effect of a Prescription Drug Coverage Policy on Risk of Falls and Overdose in Older Adults
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Tailoring Opioid Prescribing after Major Trauma
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University of Michigan Centers of Research Translation (CORT) grant
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Michigan OPEN Research in Progress (RIP) Sessions
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Statewide Opioid Recovery Drives, Disposal Strategy Development and Safe Return
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System for Opioid Overdose Surveillance
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An Open-label Study to Characterize the Pharmacokinetics and Safety of Oxycodone Hydrochloride q12h Controlled-Release (ORF) Tablets in Pediatric Patients Aged 6 to 16 Years Inclusive, Who Require Opioid Analgesia. Protocol No. OTR1020.
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Predicting Perioperative Opioid Adverse Effects and Personalizing Analgesia in Children: A Multicenter Pharmacogenetic Study
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Ligand bias in opioid receptor signaling
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Methods to increase bioavailability of the delta opioid receptor
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Molecular basis of drug addiction
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A new cellular pathway to treat addiction
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Mechanobiology of neural responses in engineered nerve integrated tissue
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Homeostatic regulation of angiotensin receptor trafficking
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Trafficking and function of mu-opioid receptor variants
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Regulation of clathrin-coated pits by the mu-opioid receptor
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Engineered surface delivery of the delta opioid receptor
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Biomarkers and Drug Discovery of TBI-Related Neurodegeneration
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The mechanistic basis of sequence-dependent receptor recycling
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Mechanisms ensuring sequence-dependent B2AR recycling
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Influence of Insulin Resistance on Cognitive, Emotional and Opioid System Functioning in Women with Polycystic Ovary Syndrome
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Endogenous opioid activity and affective state in insulin resistant women
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Evaluation of a methadone rotation protocol on patient outcomes
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Exploring the pharmacogenetics of methadone rotation in palliative care patients
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Functional Interactions of Mu and Delta Opioid Receptors
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Pharmacological Studies of NOP Receptor Agonists as Novel Analgesics
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Role of lipid rafts in adenylyl cyclase sensitization
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Discovery of New Treatments for Drug Abuse
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Allosteric Modulation of the Mu-Opioid Receptor
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Conformation-Selectivity Relations of Opioid Peptides
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Predicting postoperative opioid-related adverse events and unplanned admissions in children with sleep-disordered breathing
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An interactive app to promote safe and effective use of opioids in young children postoperatively
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Scenario-tailored opioid messaging program (STOMP): An interactive intervention to prevent analgesic-related adverse drugs events in children and adolescents
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Development of Mixed Function Opioid Peptides and Peptidomimetics
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Regulator of G protein signaling proteins differentially control opioid analgesia
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Abuse potential of a novel bifunctional opioid ligand
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Endogenous enkephalins and reward mechanisms
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Definition Development and Prevalence of New Persistent Opioid Use Following Hysterectomy
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Home Opioid Use Following Cesarean Delivery: How Many Opioid Tablets Should Obstetricians Prescribe?
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Opioid Prescribing Patterns by Obstetrics and Gynecology Residents in the United States
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Outpatient Narcotic Use After Minimally Invasive Urogynecologic Surgery
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oPIOIDS: Prevention of Iatrogenic Opioid Dependence after Surgery
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Advancing the Treatment of Chronic Pain through Individualized Opioid Cessation
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Neuroimaging Approaches to Deconstructing Acupuncture for Chronic Pain
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Centralized Pain Phenotype as a Predictor of Opioid Non-Responsiveness
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Pain Control Using Neuromodulation in Patients Undergoing Definitive Chemoradiotherapy or Radiation Therapy for Locally Advanced Head and Neck Cancer
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Investigation and Modulation of the Central Mu-Opioid Mechanism in Migraine (in vivo)
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Investigation and Modulation of the Mu-Opioid Mechanism in Chronic TMD (in vivo)
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Translation of Opiate Overdose Prevention Strategies
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Examining the Health Beliefs of People Who Inject Drugs
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Drug Use and Sexual Risk Behaviors among Emerging Adults in the ER
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Barriers to Reproductive Health Services Among Opioid-Dependent Women in Treatment
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The Effect of Mandatory Prescriber Use of Prescription Drug Monitoring Programs: Evidence from Kentucky
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Community Interventions to Reform Prescribing and Prevent Opioid Abuse in Detroit and Wayne County
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Quality Improvement Interventions to Decrease Opioid Prescribing after Hysterectomy
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Opioid Prescribing Patterns, Patient Use, and Postoperative Pain After Hysterectomy for Benign Indications
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Peripheral and Central Nervous System Correlates of Persistent Post-Hysterectomy Pain
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Opioid Peptide Synthesizing Enzymes
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Operant responding in opioid-deficient mice
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Neurochemistry/Physiology of Proopiomelanocortin Neurons
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In Vivo Chemical Monitoring Using Capillary Separations
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Opioid Glycopeptides for the treatment of Levodopa-induced dyskinesias
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Veterans Walk to Beat Back Pain
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Physician-Pharmacist Collaborative to Enhance Safe Opioid and Buprenorphine Prescribing
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Postoperative Pain Profiles, Analgesic Use, and Transition to Chronic Pain and Excessive and Prolonged Opioid Use Patterns
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An innovative methodological approach to analyzing alcohol use transitions in the context of prescription drug misuse and other health behaviors
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Opioid Modulation of Cue-Triggered “Wanting” on Amygdala
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Brief Prescription Opioid Overdose Intervention in an Urban Emergency Department
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Scientific Advisor on Governor Snyder’s Opioid Task Force
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The Impact of Legislation and Policies on Prescription Opioid Overdose Rates