Projects and Research

Status: Ongoing
Category: Research

The five-year grant will deploy Health Check-ups for Expectant Moms (HCEM), a brief smartphone- and computer-based intervention aimed at reducing sexually transmitted infections and substance use during pregnancy.

Status: Ongoing
Category: Research

Enhanced recovery pathway development following bariatric surgery.

Status: Ongoing
Category: Research

The misuse of prescription opioids over the last two decades has snowballed into a national crisis.  Simultaneously, there has been a wave of marijuana legalization at the state level. Given that, at the individual level …

Status: Ongoing
Category: Reaching Communities and Informing Policy

The objectives of this application are to provide a comprehensive assessment of opioid use disorder (OUD) treatment quality and outcomes in Medicaid, and to inform policy decisions on coverage and payment for evidence-based OUD treatments …

Status: Ongoing
Category: Research

The development, implementation and evaluation of M-OPEN Kids to establish strategies that focus on the prevention of opioid dependence in children aged 18 years and under.

Status: Ongoing
Category: Reaching Communities and Informing Policy

Michigan OPEN and Precision Health Initiative have partnered with the Schools of Theater and Voice to develop a set of contemporary music and rap that will be used for presentations to middle and early high school …

Status: Ongoing
Category: Research

Within this study, we are looking at patients responses to procedures with and without opioid use.

Status: Ongoing
Category: Research

This grant is to assist with medicinal chemistry development of lead G protein binding molecules for use as therapeutics.

Status: Ongoing
Category: Research

This grant is to support validation and triage of lead compounds derived from a screen for compounds that bind to G proteins and potential opioid analgesia.

Status: Ongoing
Category: Research

This grant is to understand the mechanisms of actions of G protein βγ subunit inhibitors at a detailed biochemical level.

Status: Ongoing
Category: Reaching Communities and Informing Policy

This project will provide clinical expertise and guidance for education and outreach on responsible prescribing of opioids and promotion of the use of MAPS. This includes partnership on in-person training and conference/educational sessions.

Status: Ongoing
Category: Reaching Communities and Informing Policy

The Opioid Project serves as a central repository of local opioid-related information and of individuals doing opioid related work locally. Our organization aims at promoting all opioid-related events in the community, and serve to connect …

Status: Ongoing
Category: Reaching Communities and Informing Policy

The Commission is reviewing the Report of Findings and Recommendations for Action from the Michigan Prescription Drug and Opioid Abuse Task Force and developing and proposing policies and an action plan to implement the recommendation …

Status: Completed
Category: Reaching Communities and Informing Policy

The focus is translation of evidence into policies and programs that can reduce the opioid overdose and addition problem through state and local action. The group will disseminate an updated version of The Prescription Opioid …

Status: Completed
Category: Research

Studies of inflammation and sepsis rely heavily on animal models to recreate complex immune responses. Many of these models require surgery to create the syndrome or to facilitate instrumentation to collect study parameters. Although standards …

Status: Ongoing
Category: Reaching Communities and Informing Policy

The aims/strategy of this project is to reduce pain medication prescribing, increase parent/caregiver education regarding opioid use and disposal and developing programs that allow surgeons to tailor postoperative opioid prescriptions based on key patient factors.

Status: Ongoing
Category: Education

In this Teach-Out, experts from the fields of Medicine, Pharmacy, Public Health, and Dentistry will help us examine the impacts of this national epidemic and answer the key questions. Find out more information here: http://ai.umich.edu/teach-out/

Status: Ongoing
Category: Research

This proposal utilizes molecular neuroimaging technology and simpler, clinically applicable, potential biomarkers to examine inter-individual variations in the function of the endogenous opioid system, a principal mechanism mediating endogenous analgesia and placebo analgesic responses. Those …

Status: Completed
Category: Research

This project provided specialized wrap around services to individuals in both a veterans treatment court and a drug court. The individuals primarily have co-occurring substance use and mental health disorders, many of who have opioid …

Status: Completed
Category: Research

This initiative entailed providing specialized wrap-around services for individuals re-entering into the greater Boston community after a period of time incarcerated in the state prison. The focus on re-entry helped address co-occurring disorders and trauma …

Status: Completed
Category: Research

This project allowed for a statewide planning effort to address the needs of justice-involved individuals with mental health disorders and co-occurring substance use disorders. The goal of the initiative was to develop strategies to build …

Status: Completed
Category: Research

This initiative provided an opportunity to advance a specialized MISSION wrap-around service to help address homelessness in select areas in Massachusetts and lead to further grant work with this model.

Status: Completed
Category: Research

This initiative entailed providing specialized wrap-around services for individuals re-entering into the greater Boston community after a period of time incarcerated in the state prison. The focus on re-entry helped address co-occurring disorders and trauma …

Status: Completed
Category: Research

This research effort examined data from a re-entry program focused on individuals with serious mental illness, many of whom had co-occurring substance use disorders, to understand any lessons learned related to the administrative data and …

Status: Completed
Category: Research

This initiative entailed providing specialized wrap-around services for women re-entering into the greater Boston community after a period of time incarcerated in the state prison for women. The focus on re-entry helped address co-occurring disorders …

Status: Completed
Category: Research

This program provided supports via peer support and case management using the MISSION-Criminal Justice model for veterans who were court-involved as an alternative to incarceration.

Status: Completed
Category: Research

This initiative entails providing specialized wrap-around services for individuals re-entering their western Massachusetts community after a period of time in the county jail. The focus on re-entry helps these individuals with their co-occurring disorders and …

Status: Ongoing
Category: Research

This project provided specialized wrap around services to individuals in drug court. The individuals primarily have co-occurring substance use and mental health disorders, many of who have opioid use disorders.

Status: Ongoing
Category: Research

This project provides specialized wrap around services to individuals in a behavioral health treatment court. The individuals primarily have co-occurring substance use and mental health disorders, many of who have opioid use disorders.

Status: Ongoing
Category: Research

This project provides specialized services to individuals with opioid use disorders who are re-entering their communities from prisons within Michigan. The program targets male and females returning to Oakland, Macomb, and Wayne Counties. This work …

Status: Completed
Category: Research

Status: Completed
Category: Education

This day-long event featuring national speakers provided an opportunity for attendees to explore and learn about an emerging public health issues.

Status: Anticipated to be available in Spring 2019
Category: Education

A massive open online course (MOOC) to help train future prescribers about prescription drug misuse and guidelines around safer prescribing

Status: Completed
Category: Research

The purpose of the pilot study is to compare the patterns of prescription opioid use, individual characteristics, driving behavior, and driving outcomes of three groups: high-dose (>50mg morphine equivalent per day [MME]) medical users, high-dose …

Status: Completed
Category: Reaching Communities and Informing Policy

CDC developed and published the guidelines to provide recommendations for the prescribing of opioid pain medication for patients 18 and older in primary care settings. Recommendations focus on the use of opioids in treating chronic …

Status: Ongoing
Category: Research

Using prescribing, consumption, and patient reported outcomes data, the project aims to develop and implement evidence based prescribing practices in the United States.

Status: Ongoing
Category: Research

The goal of this secondary analytic study using the NESARC-III database is to test a model of Sexual Minority Stress, with a particular focus on the role concordant and discordant sexual identities may play in …

Status: Ongoing
Category: Research

Goal is to determine if using a lower dose that is more cost effective shows equal outcomes to other medical control areas utilizing a larger dose.

Status: Ongoing
Category: Research

This multidisciplinary project will evaluate everyday opioid and analgesic use and knowledge in a population of adolescents and young adults – a group at high risk for analgesic misuse. Of primary interest is what this …

Status: Ongoing
Category: Reaching Communities and Informing Policy

Implementing clinical decision support tools for MiChart that improve patient safety when they are prescribed controlled substances; reducing opiate prescribing at Michigan Medicine.

Status: Ongoing
Category: Reaching Communities and Informing Policy

Ongoing communication with key legislators developing legislation regarding opioids. Provide consultation and subject expertise; provided expertise to develop language for new legislation that will affect the state’s prescription drug monitoring program (PDMP) revision, as well …

Status: Ongoing
Category: Education, Research

Medication Assisted Therapy (MAT) is the “gold standard” of treatment for opioid use disorders (OUDs) and has been shown to reduce overdose mortality. However, many individuals receiving treatment for OUDs do not receive MAT, in …

Status: Ongoing
Category: Reaching Communities and Informing Policy, Research

Heroin overdose rates have increased in recent years, but there is little understanding of the factors that have led to this increase. It has been hypothesized, but not demonstrated, that reduced access to opioids due …

Status: Ongoing
Category: Research

This study is a pragmatic randomized controlled trial of a motivational intervention to improve safe handling and storage and reduce overdose risk behaviors among veterans prescribed chronic opioid therapy in VA primary care clinics. The …

Status: Ongoing
Category: Research

This study is a pilot randomized controlled trial of a three-session motivational intervention to reduce overdose and HIV risk behaviors among patients at a residential addictions treatment center. After screening, 138 participants were selected for …

Status: Ongoing
Category: Research

This is a randomized controlled trial of an artificial intelligence-enhanced intervention to reduce risky opioid use among emergency department (ED) patients with recent non-medical opioid use and receiving an opioid at the ED. The intervention …

Status: Ongoing
Category: Research

A randomized controlled trial of a psychosocial intervention to address co-occurring pain and addiction.

Status: Ongoing
Category: Research

Although a growing literature finds that certain opioid-related policies—including prescription drug monitoring programs (PDMPs) and pain clinic laws—are associated with reductions in opioid prescribing and even prescription opioid-related overdose deaths, much is still unknown about …

Status: Ongoing
Category: Research

This geospatial mapping research project seeks to assess the geographical correlation between opioid-related overdose mortality and opioid addiction treatment provider supply and provision. We will seek to answer, using publicly available datasets, the following questions: …

Status: Ongoing
Category: Education

New, required session for third-year medical students, providing information about policies and practices related to opioids.

Status: Ongoing
Category: Reaching Communities and Informing Policy

Four county region-wide initiative (Washtenaw, Livingston, Lenawee, and Monroe) to reduce opioid overdoses through providing community education, increasing training and access to naloxone, and engaging prescribers to improve prescribing practices through information and policy modifications.

Status: Ongoing
Category: Reaching Communities and Informing Policy

Our goal of this descriptive mixed-method demonstration study is to further sustain our community-academic partnership through creating a web-based naloxone education intervention and evaluating the feasibility, acceptability, usability, and quality of this intervention. The web-based …

Status: Ongoing
Category: Reaching Communities and Informing Policy

The goal of this study is to determine the feasibility and acceptability of a didactic naloxone educational intervention for LEOs as the initial step in developing and testing a new intervention – an educational web-based …

Status: Ongoing
Category: Reaching Communities and Informing Policy

The goal of this project is to further build our existing partnership and develop organizational capacity among the University of Michigan, WCSO, and Home of New Vision (substance use treatment center) to develop an innovative …

Status: Ongoing
Category: Reaching Communities and Informing Policy

Held every two weeks at Dominos Farms for chronic pain patients and family members. Educates about all potential problems with using opioids to treat chronic pain.

Status: Ongoing
Category: Research

A large number of patients present for elective surgery with a history of active opioid use for pain management. Recent work calls into question the benefit of opioid use for the treatment of chronic pain. …

Status: Ongoing
Category: Research

The goal of this secondary analytic study is to use two waves of existing nationally representative longitudinal data to examine the course of drug use disorders, including opioid use disorder, along with longitudinal changes in …

Status: Ongoing
Category: Research

The objective of this project is to improve the understanding of medical and nonmedical use of opioid analgesics as well as other controlled medications among 18-year-olds and their transition to adulthood.

Status: Ongoing
Category: Reaching Communities and Informing Policy, Research

Although individual-level associations between injury and benzodiazepine use for older adults are well established, the effects of new coverage for benzodiazepines in 2013 on population-level injury trends in older adults on Medicare Part D has …

Status: Ongoing
Category: Research

The overarching purpose of this study is to generate robust pilot data toward a future R01-level proposal that will implement a multifaceted intervention to reduce excess prescription opioids in the community. In the state of …

Status: Ongoing
Category: Research

This large center grant hypothesizes that the same neural signature seen in fibromyalgia on brain imaging and quantitative sensory testing is also present in subsets of individuals with osteoarthritis, rheumatoid arthritis and carpal tunnel syndrome, …

Status: Ongoing
Category: Education

Monthly sessions with objectives to: 1) Review and give feedback on current research in progress relevant to opioid use and misuse; 2) facilitate research network focusing on opioid topics; and 3) engage trainees of all …

Status: Ongoing
Category: Reaching Communities and Informing Policy

This program’s objectives are: removing excess opioids from Michigan communities by organizing statewide opioid recovery drives, creating opioid disposal strategies, and identifying methods to improve opioid return.

Status: Ongoing
Category: Research

The goal of this project is to create a real-time surveillance system of fatal and non-fatal overdoses. The SOS system links fatal and non-fatal overdose data from emergency departments, ambulance systems (EMS), and medical examiners. …

Status: Completed
Category: Research

The purpose of this study was to characterize the pharmacokinetics and safety of ORF tablets in pediatric patients aged 6 to 16 years, inclusive.

Status: Completed
Category: Research

Status: Completed
Category: Research

Status: Completed
Category: Research

Status: Completed
Category: Research

Status: Completed
Category: Research

Status: Completed
Category: Research

Status:
Category: Research

Status: Completed
Category: Research

Status: Completed
Category: Research

Status: Ongoing
Category: Research

Status: Ongoing
Category: Research

Status: Ongoing
Category: Research

Status: Ongoing
Category: Research

Status: Completed
Category: Research

This study examines the role of the endogenous μ-opioid system in women with insulin-resistant PCOS compared to controls.

Status: Ongoing
Category: Research

This study examines the role of the endogenous μ-opioid system in mediating the relationship between metabolic dysfunction and depressive symptoms in reproductive aged women.

Status: Ongoing
Category: Research

The rotation to methadone for patients intolerant or refractory to traditional opiates is complex. Based on published literature, there are a variety of ways this can be done. Our institution has developed a standardized protocol …

Status: Ongoing
Category: Research

There is a paucity of data on the pharmacogenetic impact on methadone for pain. This study is part of a larger project that is trying to determine what impact, if any, the pharmacogenetics of methadone …

Status: Completed
Category: Research

This proposal developed opioid compounds that act at more than one type of receptor as analgesics with reduced tolerance and dependence liability.

Status: Completed
Category: Research

The project aimed to identify the endogenous peptide nociceptin and its analogs as efficacious non-opioid analgesics without abuse liability.

Status: Completed
Category: Research

This project studied the sensitization of the enzyme adenylate cyclase as a marker for opioid dependence.

Status: Ongoing
Category: Research

To devise new small molecules based on the opioid treatment drug buprenorphine as potential medications to prevent polydrug abuse.

Status: Ongoing
Category: Research

Allosteric modulators are drugs that bind to unique sites on drug receptors to modify their function. We hypothesize that positive allosteric modulators of opioid receptors will enhance the action of the body’s own endogenous pain-relieving …

Status: Completed
Category: Research

This project was aimed at the development of novel bifunctional opioid peptides and peptidomimetics and elucidating the details of the ligand-receptor interactions that distinguish binding to the different opioid receptor subtypes.

Status: Completed
Category: Research

This study utilized the STBUR tool (developed by us) as a risk assessment tool to identify children with sleep-disordered breathing who may be at risk for postoperative opioid-related adverse events.

Status: Ongoing
Category: Research

The goal of this project is to develop an interactive app to promote safe opioid use in young children.

Status: Ongoing
Category: Research

This study utilizes a series of risk benefit scenarios to educate parents regarding the risk and benefits of opioid use in children as a way to help educate and promote safe decision-making.

Status: Ongoing
Category: Research

This grant supports research aimed at the development of two series of bioavailable MOR agonist/DOR antagonist bifunctional opioid ligands: one a peptide series and the second a diverse set of peptidomimetics designed to incorporate the …

Status: Ongoing
Category: Research

Regulators of G proteins signaling (RGS) proteins are intracellular proteins that regulate opioid actions. The aim is to identify RGS proteins as novel drug targets for the management of pain and/or dependence on opioids.

Status: Ongoing
Category: Research

The goal of this project is to examine the effects of a novel opioid ligand AAH8 in models of chronic pain and for adverse effects.

Status: Ongoing
Category: Research

The goal of this project is to investigate the role of the endogenous opioid systems in regulating the reinforcing properties of drug-associated stimuli that serve as conditioned reinforcers.

Status: Completed
Category: Research

Using a large administrative database of women with a single national private health insurer, we determined a definition for “new persistent opioid use” to be: ≥ 2 opioid fills within six months of hysterectomy with …

Status: Completed
Category: Research

In the first two weeks postpartum, 75% of women used 45 or fewer opioid tablets. Operative time over one hour and increased number of opioid tablets prescribed are factors associated with higher postpartum opioid use.

Status: Completed
Category: Research

Opioid prescribing practices of Ob/Gyn residents are influenced by region of country, program-type, and factors related to hospital culture and personal insight.

Status: Completed
Category: Research

Following minimally-invasive urogynecologic surgery, women were prescribed 3x more opioids than they actually used.

Status: Ongoing
Category: Research

This prospective 5-year study seeks to define the normative consumption of opioids following surgery and the phenotypic risk factors for opioid dependence following procedural care. In addition, we will define the provider-level beliefs and behaviors …

Status: Ongoing
Category: Research

This is a K23 award that aims to 1) characterize the unique factors that influence opioid use and identify potential targets for an opioid cessation intervention, 2) develop the content of an opioid cessation intervention …

Status: Ongoing
Category: Research

Our overall goal is to evaluate the impact of acupuncture-induced somatosensory afference on altered neurobiology and analgesia in fibromyalgia.

Status: Ongoing
Category: Research

Performs both opioid PET and fMRI and individuals undergoing knee arthroplasty and hypothesizes that the centralized pain phenotype is characterized by opioid non-responsiveness because the endogenous opioid system is participating in the pathogenesis of centralized …

Status: Ongoing
Category: Research

Cancer pain represents a clinical problem in which our empirical conventional treatments offer uncertain relief for a large number of patients. Many therapies for cancer pain that focus on mechanical and peripheral factors are short-lasting …

Status: Ongoing
Category: Research

Although MRI-based techniques have provided insights into the function of brain regions involved in migraine, there is little understanding of the molecular mechanisms affected during the course of this disorder. Understanding this process in vivo …

Status: Ongoing
Category: Research

Approximately 10% of TMD patients will not experience an improvement of their symptoms and around 75% of patients who fail to respond to conservative treatments are also not suitable for TM joint surgery. Earlier studies …

Status: Ongoing
Category: Research

This study will translate the intervention materials from a prior CDC/UM Injury Center project of a behavioral intervention to reduce overdose risk behaviors combined with naloxone education and distribution.

Status: Completed
Category: Research

This dissertation project involved recruiting 91 people who inject drugs from needle exchange programs in Ohio and Michigan. Participants, nearly all of whom used heroin, reported on their injection-related health beliefs and behaviors, including steps …

Status: Ongoing
Category: Research

This project focuses on developing and testing the feasibility of a brief intervention, extended via mobile booster messages, targeting drug use (including opioids) and sexual risk behaviors among emerging adults seeking care in an urban …

Status: Completed
Category: Research

The goal of the project was to study the epidemiology of reproductive health service use for women in substance use treatment and explain the perceived barriers and facilitators to integrating reproductive healthcare to substance use …

Status: Ongoing
Category: Research

In 2012, Kentucky passed comprehensive legislation aimed at addressing the problem of prescription opioid abuse. A critical element of this reform is a requirement that prescribers register with the state’s prescription drug monitoring program (PDMP) …

Status: Ongoing
Category: Education, Reaching Communities and Informing Policy, Research

The Detroit Opioid Prevention Collaborative is a partnership of the University of Michigan, Detroit Wayne Mental Health Authority and the Altarum Institute, working through the Empowered Communities for a Healthier Nation Initiative with various community …

Status: Ongoing
Category: Research

The objective of this prospective Quality Improvement project is to prospectively quantify the effect of quality improvement interventions aimed at decreasing the amount of opioids prescribed and used following hysterectomy. The three main practice changes …

Status: Completed
Category: Research

This prospective observational cohort study examined opioid prescribing patterns, self-reported patient use and postoperative pain following ~100 consecutive hysterectomies performed at the University of Michigan for benign indications. We found that patients report using about …

Status: Ongoing
Category: Research

Chronic Pelvic Pain (CPP) is a debilitating problem that afflicts 15-20% of women in the United States. Although over 200,000 hysterectomies are performed annually for the treatment of CPP, 1 in 4 women undergo the …

Status: Ongoing
Category: Research

PCSKI (Prohormone convertase 1/3) is the major processing enzyme responsible for the generation of biologically active endogenous opioid peptides (and others) from their respective prohormones. This grant will generate a series of mutations in the …

Status: Completed
Category: Research

This project studied mutant mice selectively lacking beta-endorphin, proenkephalin, prodynorphin or the combination of beta-endorphin and proenkephalin for the reinforcing effects and reward from normal diet chow, sucrose and ethanol using progressive ratio operant responding, …

Status: Ongoing
Category: Research

This project studies the neurocircuitry of POMC neurons by using a combination of genetic and classical tract tracing methods to identify the source and phenotype of afferent and efferent neurons to the arcuate POMC neurons, …

Status: Ongoing
Category: Research

Development and application of new techniques for measuring neurotransmitters in vivo.

Status: Completed
Category: Research

Evaluate the in vivo pharmacodynamics of novel peptide drugs used for treating dyskinesia resulting from L-DOPA treatment in Parkinsonian animals.

Status: Completed
Category: Research

This study was a randomized controlled trial of a pedometer-based, Internet-mediated intervention for Veterans with chronic back pain. The primary outcome was back pain-related disability as measured using the Roland Morris Disability Questionnaire (RDQ). The …

Status: Ongoing
Category: Research

The funded project is to embed a clinical pharmacist with specialized training in pain management and behavioral counseling techniques into a physician directed treatment team dealing with patients at risk for opioid abuse. The aim …

Status:
Category: Research

This multi-center study utilizes the perioperative database provided by the Multicenter Perioperative Outcomes Group (MPOG) and adds an enhanced observational component that focuses on select preoperative, postoperative and discharge variables to determine their impact on …

Status: Ongoing
Category: Research

Using substance use daily timeline calendar data, we will determine frequency, and predictors of past 90-day overdose risk behavior (i.e. simultaneous alcohol and prescription opioid/sedative use). Predictor effects, focusing on alcohol use transitions, will be …

Status: Completed
Category: Research

Optogenetic studies of brain mechanisms of liking and wanting for rewards, and mechanisms of addiction.

Status: Completed
Category: Research

This randomized controlled trial was set in a single emergency department (ED) in which, 204 adult, English-speaking patients seeking care who reported prescription opioid misuse during the prior 3 months were recruited. Patients were randomized …

Status: Completed
Category: Reaching Communities and Informing Policy

The Michigan Prescription Drug and Opioid Abuse Task Force is a result of the call for a comprehensive plan to address prescription drug and opioid abuse in Gov. Snyder’s 2015 State of the State address.

Status: Ongoing
Category: Reaching Communities and Informing Policy

The objective of this study will be to examine the impact of enactment of seven specific types of state laws on overdose rates.